General Information

  • ID:  hor004108
  • Uniprot ID:  P82619
  • Protein name:  Pyrokinin-4
  • Gene name:  NA
  • Organism:  Periplaneta americana (American cockroach) (Blatta americana)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  Corpora cardiaca.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Periplaneta (genus), Blattinae (subfamily), Blattidae (family), Blattoidea (superfamily), Blattodea (order), Dictyoptera (superorder), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  DHLPHDVYSPRL
  • Length:  12(1-12)
  • Propeptide:  DHLPHDVYSPRL
  • Signal peptide:  NA
  • Modification:  T12 Leucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Mediates visceral muscle contractile activity
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004108_AF2.pdbhor004108_ESM.pdb

Physical Information

Mass: 164499 Formula: C65H97N19O19
Absent amino acids: ACEFGIKMNQTW Common amino acids: DHLP
pI: 6.5 Basic residues: 3
Polar residues: 2 Hydrophobic residues: 3
Hydrophobicity: -95 Boman Index: -3134
Half-Life: 1.1 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 89.17
Instability Index: 4926.67 Extinction Coefficient cystines: 1490
Absorbance 280nm: 135.45

Literature

  • PubMed ID:  10196736
  • Title:  Differential Distribution of Pyrokinin-Isoforms in Cerebral and Abdominal Neurohemal Organs of the American Cockroach